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In enterocytes and macrophages, sequestration of hepcidin leads to increased intracellular ferritin levels, preventing iron efflux and causing hyperferritinemia [104]

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As a subtype of glial cells vital for retina structural support, cellular homeostasis maintenance, and blood-retina barrier preservation, its reactivation would decrease lglutamic acid uptake, which results in excitotoxicity, as well as sabotage the integrity of the blood-retina barrier, leading to ultimate retinal ganglia cell death and vision damage (Ren et al., 2020)

Humans express over 20 genes that encode proteins exhibiting all trans or cis -retinol dehydrogenase activity

Indeed, while GSH negatively impact with the expression of late viral proteins (in particular hemagglutinin and matrix), Bcl-2 impairs nuclear-cytoplasmic translocation of viral ribonucleoproteins (vRNPs)